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IV. CREATINE CONTENT OF HYPERTENSIVE HYPERTROPHIED HEARTS OF RATS FED WHOLE DRIED MEAT

ALFRED CHANUTIN, Ph.D.; STEPHAN LUDEWIG, Ph.D.

Arch Intern Med. 1936;57(5):887-892.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Factors affecting the creatine concentration of the ventricles of the heart have been studied in experimental animals¹ and in human subjects.² The present investigation was undertaken to study the deposition and concentration of creatine in the cardiac muscle of the rat when there were wide variations in the amount of whole dried meat in the animal's diet and when cardiac hypertrophy was produced secondary to hypertension after partial nephrectomy.³

METHODS

The rats used in this study were of the Wistar stock and were maintained on a stock diet until they were between 60 and 70 days old. At that time they were subjected to a two stage operation, and immediately thereafter they were placed on one of the experimental diets listed in table 1. These diets differed only in the percentage of the whole dried meat which was the principal source of protein. To prepare the whole . . . [Full Text PDF of this Article]

Author Affiliations
UNIVERSITY, VA.

From the laboratory of physiologic chemistry, University of Virginia.

Footnotes
This investigation was aided by a grant from the National Live Stock and Meat Board.

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