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EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMYV. DIETS CONTAINING WHOLE DRIED MEAT
ALFRED CHANUTIN, Ph.D.;
STEPHAN LUDEWIG, Ph.D.
Arch Intern Med. 1936;58(1):60-80.
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In previous reports1 it was shown that partial nephrectomy is followed by a progressive development of polyuria, albuminuria, nitrogen retention, renal hypertrophy, hypertension and cardiac hypertrophy. Feeding different concentrations of whole dried liver produced variations in this syndrome and in the pathologic changes in the kidney. The present report is concerned with the effect of whole meat on the partially nephrectomized rat. It demonstrates that whole dried meat causes changes in the syndrome similar to those produced by diets containing liver.
EXPERIMENTAL METHODS
Details of the experimental procedures have been presented in previous papers.1 In these as in former experiments the control animals included rats with both kidneys intact and unilaterally nephrectomized rats. The partially nephrectomized animals were those in which from 80 to 90 per cent of the total renal tissue was removed by a two stage operation.
Two procedures were used in the determination of renal
. . . [Full Text PDF of this Article]
Author Affiliations
UNIVERSITY, VA.
From the Laboratory of Physiological Chemistry, the University of Virginia.
Footnotes
The pathologic study was made by Dr. Paul Kimmelstiel of the Department of Pathology, the Medical College of Virginia.
This investigation was made possible by a grant from the National Live Stock and Meat Board and by the Edward N. Gibbs Prize Fund of the New York Academy of Medicine.
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