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VI. THE RELATION BETWEEN KIDNEY FUNCTION, KIDNEY WEIGHT AND SURFACE AREA IN INTACT AND UNILATERALLY NEPHRECTOMIZED RATS FED WHOLE DRIED MEAT DIETS

ALFRED CHANUTIN, Ph.D.; STEPHAN LUDEWIG, Ph.D.

Arch Intern Med. 1936;58(1):81-88.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The determination of the urea ratio, urea in 1 hour's urine blood' of Addis urea in 100 cc. of blood and his collaborators¹ has proved to be a satisfactory method for the estimation of the percentage of functioning renal tissue. It was found to be the best functional test to give an approximation of the quantitative and structural changes caused by unilateral nephrectomy² and by uranium "nephritis."³ The magnitude of the Addis ratio was found to be directly related to the size of the kidneys in intact rats,⁴ in rabbits⁵ and in human beings.⁶ A relationship between the urea ratio and the surface area in the dog⁷ and in man⁶ has been demonstrated. It has also been shown that a relationship exists between the area of the body surface and kidney weight in the rat,⁸ the rabbit,⁵ the dog⁹ and man.⁶ It would appear that renal function, . . . [Full Text PDF of this Article]

Author Affiliations
UNIVERSITY, VA.

From the Laboratory of Physiological Chemistry, the University of Virginia.

Footnotes
This investigation was made possible by a grant from the National Live Stock and Meat Board and by the Edward N. Gibbs Prize Fund of the New York Academy of Medicine.

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