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ITALO D. PUPPEL, M.D.; GEORGE M. CURTIS, Ph.D., M.D.

Arch Intern Med. 1936;58(6):957-977.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A disturbance of the calcium balance has been found in thyroid disease.¹ Apparently there is a relationship between the calcium and iodine intake, the normal function of the thyroid gland and the development of goiter.² Consequently, we became interested in determining any existing correlation between the total calcium and iodine metabolism and thyroid disease in man. For at least a century calcium has been considered a factor in the production of goiter. As early as 1837 McClelland³ reported this belief. The iodine deficiency theory of goiter, which has been accepted by many, was advocated by Maffoni⁴ in 1846, by Prevost⁵ in 1849 and by Chatin⁶ in 1852.

Reviews of the earlier literature on calcium metabolism in thyroid disease have been presented.⁷ However, until Aub and his associates¹ reported their systematic studies in 1929, the evidence for a disturbance of calcium metabolism remained inconclusive. The true nature of this . . . [Full Text PDF of this Article]

Author Affiliations
COLUMBUS, OHIO

From the Department of Medical and Surgical Research, the University Hospital, and the Department of Surgery of the Ohio State University.

Footnotes
This investigation has been aided by a grant from Mr. William Wallace Kincaid, Ellerslie-on-Niagara, New York.

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