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INTAKE OF POTASSIUM, AN IMPORTANT CONSIDERATION IN ADDISON'S DISEASEA METABOLIC STUDY
RUSSELL M. WILDER, M.D., Ph.D.;
EDWARD C. KENDALL, Ph.D.;
ALBERT M. SNELL, M.D.;
EDWIN J. KEPLER, M.D.;
EDWARD H. RYNEARSON, M.D.;
MILDRED ADAMS, Ph.D.
Arch Intern Med. 1937;59(3):367-393.
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It has long been recognized that injections of sodium chloride are of benefit in the treatment of the characteristic crises of Addison's disease, but it was the quantitative investigation of the electrolytes of the plasma by Loeb and his associates1 and by Harrop and his associates2 that first revealed why large amounts of sodium and chloride are required effectively to combat such crises. Their experiments demonstrated that the loss of ions of sodium and chloride is one of the principal disturbances leading to the development of the crisis and that the crisis can be prevented by a quantitative replacement of these ions. However, the results obtained by treating patients only with sodium chloride have remained less satisfactory than those obtained when extract of adrenal cortex has been given, and no one has succeeded in maintaining indefinitely the life of a completely adrenalectomized dog by administering only sodium chloride.
. . . [Full Text PDF of this Article]
Author Affiliations
ROCHESTER, MINN.
From the Division of Medicine of the Mayo Clinic (Drs. Wilder, Snell, Kepler and Rynearson) and the Division of Biochemistry of the Mayo Foundation (Drs. Kendall and Adams).
Footnotes
Read before the Association of American Physicians, Atlantic City, N. J., May 5, 1936. An abstract was printed in the Proceedings of the Staff Meetings of the Mayo Clinic (11:273-283 [April 29] 1936).
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