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EDWARD J. STIEGLITZ, M.D.; ALICE E. PALMER, B.S.

Arch Intern Med. 1937;59(4):620-630.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Knowledge of the physiology of the nitrites is much confused. This may be attributed in part to the previous lack of a test sufficiently sensitive yet specific for detecting the presence of or measuring extremely minute quantities of nitrite. Very minute doses of nitrite have profound physiologic effects. Although an immense amount of investigation has yielded many significant observations, many enigmas still remain unsolved in this complex field.

Glyceryl trinitrate was discovered by Sobrero¹ in 1847, and the first physiologic studies on nitrites were initiated. Since then the accumulated literature has become enormous, and only a few significant papers can be reviewed here. Early analytic studies² revealed nitrite in many tissues but in some only after the tissues were ground. Liver reduces nitrate to nitrite.³ The mechanism of this reduction is not definitely determined, but a vital process is presumably involved because this reduction is completely abolished . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the George Herbert Jones Chemical Laboratory and the Department of Physiology, the University of Chicago.

Footnotes
Julius Stieglitz Junior Fellow.

This work was supported by The Chemical Foundation through the Julius Stieglitz Fund for Research in Chemistry Applied to Medicine.

Read before the Section on Pathology and Physiology at the Eighty-Seventh Annual Session of the American Medical Association, Kansas City, Mo., May 13, 1936.

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