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MITCHELL I. RUBIN, M.D.; MILTON RAPOPORT, M.D.

Arch Intern Med. 1937;59(4):714-723.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous study it was demonstrated that the magnesium ion is capable of preventing the contraction of smooth muscle both in vitro and in vivo.¹ In a large percentage of guinea-pigs passively sensitized to horse serum an intravenous injection of magnesium chloride just prior to the injection of a shocking dose of horse serum prevented the appearance of anaphylactic shock. Similarly, the addition of magnesium chloride in isotonic amounts to the fluid of the Dale bath in which were suspended uterine strips from sensitized guinea-pigs prevented the contraction of the strips when antigen was added.

EXPERIMENTS

The present studies were concerned with the effect of the magnesium ion on the contraction of the smooth muscle of the vascular system in the intact animal. White rats (Wistar strain) were utilized as the experimental animals, and the systolic blood pressure was used as an index of the presence or absence . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Pediatrics, the School of Medicine, the University of Pennsylvania, and the Children's Hospital of Philadelphia.

Footnotes
Aided by a grant from Mead Johnson & Co.

A preliminary report of this study was presented before the Society for Pediatric Research, Atlantic City, N. J., May 5, 1936.

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