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A REVIEW OF RECENT LITERATURE

WILLIAM S. McCANN, M.D.

Arch Intern Med. 1937;60(1):167-175.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EXPERIMENTAL GLOMERULONEPHRITIS

The past year has been characterized by marked progress in attempts to produce glomerulonephritis experimentally. These attempts have been recently reviewed by Masugi,¹ who was one of the earliest to achieve experimental glomerulonephritis; by Ahlström,² and by Smadel.³ All of these workers have utilized cytotoxic serum in its production.

Ahlström² began by investigating the action of Dick toxin, finding that it had a weak nephrotoxic action and produced only a few focal degenerative changes when injected into the renal arteries of normal rabbits or of rabbits which had been previously sensitized to Dick toxin.

Ahlström found also that when serum was injected into the renal arteries of sensitized animals most of them showed only perivascular cell infiltrates, frequently localized about the afferent glomerular artery, in which occasionally hyaline thrombi were observed and in some instances slight glomerular changes as well. When, however, animals which . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, N. Y.

From the Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Medical Clinic of the Strong Memorial and Rochester Municipal Hospitals.

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