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RICHARD W. CRAGG, M.D.; MARSCHELLE H. POWER, Ph.D.; MARTIN C. LINDEM, M.D.

Arch Intern Med. 1937;60(1):88-99.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The syndrome commonly known as spontaneous hypoglycemia was recognized by Seale Harris¹ in 1924 and was attributed by him to "hyperinsulinism," in contrast to the supposed "hypo-insulinism" of diabetes. The possibility of true hyperinsulinism was first demonstrated in 1927 by Wilder, Allan, Power and Robertson² in a report of a case of severe hypoglycemia in which carcinoma of the islands of Langerhans with extensive metastasis to the liver and lymph nodes was noted at necropsy. The cells of the metastatic nodules in the liver bore a striking resemblance to the cells of the islands of Langerhans, and an extract of the hepatic nodules was found to possess the property of markedly lowering the concentration of sugar in the blood when injected into rabbits.

Since that report there have appeared in the literature (recently reviewed by Whipple and Frantz³ and by Wilder⁴) numerous descriptions of cases of . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Pathology; ROCHESTER, MINN.; SALT LAKE CITY

From the Division of Biochemistry, the Mayo Foundation.

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