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ADELAIDE P. BARER, Ph.D.; W. M. FOWLER, M.D.

Arch Intern Med. 1937;60(3):474-481.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The influence of copper on the formation of hemoglobin is a problem which has not been completely solved, and the literature abounds in conflicting reports on the subject. Elvehjem¹ has recently summarized the work on the biologic significance of copper, and the reader is referred to this paper for a comprehensive review and bibliography. It has been found that in the experimental nutritional anemia of animals neither iron nor copper alone is effective in producing regeneration of hemoglobin, but when iron is given in combination with a small amount of copper a rapid increase in the hemoglobin content of the blood ensues. The work of Whipple² on experimental hemorrhagic anemia in dogs has not entirely confirmed these results. He found that in certain instances a combination of iron and copper was more beneficial than iron alone but that this was not consistently true. It is possible that a . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Internal Medicine, the State University of Iowa.

Footnotes
Supported in part by a grant from Eli Lilly & Co.

This work was begun in association with Dr. C. W. Baldridge, who died on Nov. 22, 1934.

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