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LOUIS J. SOFFER, M.D.; D. ALFRED DANTES, M.D.; HARRY SOBOTKA, Ph.D.

Arch Intern Med. 1937;60(3):509-521.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Investigations of the effects of experimental hepatic injury on the chemical constituents of the blood have been of limited character. Most of the investigations have been concerned with changes in the nonprotein nitrogen, urea and uric acid of the blood and alterations in carbohydrate metabolism. Minot and Cutler¹ have described increases in the guanidine base and accumulations of lactic acid in the blood in instances of damage to the parenchyma of the liver produced experimentally by carbon tetrachloride poisoning. Occasional clinical reports² have described the reduction of plasma chlorides in instances of carbon tetrachloride intoxication, while an increase in the concentration of lactic acid in the blood of patients with extensive hepatic disease has been described by several authors.³

In a previous paper one of us (L. J. S.⁴) reported the existence of changes in the electrolytes of the blood following the production of extensive hepatic . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Service of Dr. George Baehr and the Laboratories of the Mount Sinai Hospital.

Footnotes
Aided by a grant from Merck & Co., Inc.

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