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II. UTILIZATION OF INTRAVENOUSLY INJECTED SODIUM d-LACTATE BY PATIENTS WITH ACUTE DIFFUSE PARENCHYMAL INJURY OF THE LIVER

LOUIS J. SOFFER, M.D.; D. ALFRED DANTES, M.D.; ROBERT NEWBURGER, M.D.; HARRY SOBOTKA, Ph.D.

Arch Intern Med. 1937;60(5):882-886.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The metabolism of racemic sodium lactate in the presence of disease of the liver has been studied by Schumacher¹ and Hartmann and Senn.² The two optically active enantiomer components constituting racemic lactate differ from each other, according to Cori and Cori,³ with regard to the manner of their biologic utilization. The l form when injected or ingested cannot be converted into glycogen or any intermediate carbohydrate, but its greater portion reappears in the urine, whereas the remainder may be accounted for by the formation of accessory carbon dioxide. On the other hand, d-lactate is converted into glycogen by the liver.⁴ Hartmann and Senn concluded that the degree of glycogen formation from racemic lactate depends on the proportion of the d form present in the mixture.

It seems, therefore, of importance to study the fate of the optically active components separately, especially that of the d . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Service of Dr. George Baehr and the Laboratories of the Mount Sinai Hospital.

Footnotes
Aided by a grant from the Committee on Scientific Research of the American Medical Association.

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