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BIOPSIES OF BONE MARROW

OLIVER P. JONES, Ph.D.

Arch Intern Med. 1937;60(6):1002-1015.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been aptly mentioned by Heck and Watkins¹ that there is little in the American medical literature concerning the value of neutrophils in pernicious anemia as an aid to diagnosis. There is practically nothing in the American literature dealing with the origin of these cells. Cooke,² after studying cells in the peripheral blood for many years, finally advanced three hypotheses to explain the source of large hypersegmented hyperpolymorphic neutrophils in pernicious anemia, which he called macropolycytes I, II, and III. These are the same cells which have been called pernicious anemia neutrophils and have been accurately described by Downey.³ As will be seen later, the various types of macropolycytes described by Cooke are in reality morphologic variations of cells belonging to the same series of pathologic neutrophils.

The origin of these atypical cells was contemplated in the following hypotheses formulated by Cooke:² First, there is . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Hematological Laboratory, the Department of Anatomy, the University of Minnesota Medical School.

Footnotes
Dr. Jones is now a member of the Department of Anatomy, the University of Buffalo Medical School, Buffalo.

Presented before the Minnesota Pathological Society, November 1936, and demonstrated at the meetings of the American Association of Anatomists, Toronto, Canada, March 25 to 27, 1937.

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