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EFFECTS OF EXTRACTS OF KIDNEYS OF NORMAL DOGS AND OF DOGS WITH RENAL HYPERTENSION ON BLOOD PRESSURE OF RATS

T. R. HARRISON, M.D.; ALFRED BLALOCK, M.D.; MORTON F. MASON, Ph.D.; JOHN R. WILLIAMS, Jr., M.D.

Arch Intern Med. 1937;60(6):1058-1068.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Goldblatt and his co-workers¹ have recently shown that a sustained increase in blood pressure may be produced in dogs by partial occlusion of the renal arteries. This observation has been confirmed by numerous investigators, including Page,² Prinzmetal and Friedman³ and ourselves. Since the hypertension is not relieved by denervation of the kidney, can be produced in animals subjected to previous renal denervation² and occurs even when the kidney has been transplanted into the neck,⁴ the rise in blood pressure appears to be of "chemical" rather than "nervous" origin.

Hartwich⁵ showed that ureteral ligation caused a rise in blood pressure in dogs. Similar results were reported by others,⁶ who found that previous denervation of the kidney did not prevent the effect. It has recently been observed⁷ that ureteral ligation may cause a well marked diminution of the blood flow through the kidneys of unanesthetized dogs. Since ischemia of the . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN.

From the departments of Medicine, Surgery and Biochemistry, Vanderbilt University.

Footnotes
This study was aided by a grant from the Division of Sciences of the Rockefeller Foundation.

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