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BIOLOGIC FACTORS IN ITS DEVELOPMENT

M. FRIEDMAN, M.D.; L. N. KATZ, M.D.; K. HOWELL, M.D.

Arch Intern Med. 1938;61(1):95-118.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There are two distinct main aspects to the consideration of subacute bacterial endocarditis: (1) the mode of infection of the cardiac valves and (2) the factors involved in the continuance of the growth on the valve. The second aspect was the subject of the present investigation. We felt that it might prove to be of practical value to discover why infection due to a relatively nonvirulent organism persists on the cardiac valves. To this end the behavior of Streptococcus viridans was noted in various types of serum and whole blood, and the fate of the bacterium was investigated when placed in the blood stream, on a cardiac valve and in certain other tissues of the normal living dog.

Horder,¹ Schottmüller² and Libman and Celler³ first observed the morphologic characteristics of Str. viridans and noted its relative nonvirulence. Since their observations innumerable studies have been made of the . . . [Full Text PDF of this Article]

Author Affiliations
With the Collaboration of E. LINDNER AND M. MENDLOWITZ, M.D.; CHICAGO

From the Cardiovascular Department and the Department of Bacteriology, Michael Reese Hospital.

Footnotes
Aided by the A. D. Nast Fund for Cardiac Research.

Emanuel Libman Fellow, Mount Sinai Hospital, New York.

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