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WITH STUDIES OF THE ACID-BASE EQUILIBRIUM

THOMAS SIMPSON, M.B., Ch.B.; M. HERBERT BARKER, M.D.

Arch Intern Med. 1938;61(2):208-222.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For many years different workers have attempted to show that voluntary hyperpnea can produce seizures in a patient with epilepsy. Numerous theories have been advanced for the mode of action, all of them being connected either with changes in the concentration of specific ions in the blood or with alterations in the acid-base equilibrium. In voluntary hyperpnea a state of alkalosis is encountered. Because of this, Lennox¹ suggested, for the first time, that anoxia may play a part in the production of seizures, in that in alkalosis the blood gives up oxygen less readily, thereby causing oxygen lack in the tissues.

On the basis of this premise it should be possible to predict the occurrence of seizures as the result of voluntary hyperpnea. A review of the literature shows a lack of agreement as to the incidence and mechanism of the production of seizures by hyperventilation or anoxia.² . . . [Full Text PDF of this Article]

Author Affiliations
LEEDS, ENGLAND; CHICAGO

From the Department of Experimental Medicine and the Department of Nervous and Mental Diseases, Northwestern University Medical School.

Footnotes
The Linde Air Products Company donated the nitrogen for use in these experiments.

Fellow in the Department of Experimental Medicine, Northwestern University Medical School.

This study was made possible by grants from the Minnie Frances Kleman Fund and from the Council on Physical Therapy of the American Medical Association.

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