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METABOLISM OF VITAMIN C IN RHEUMATIC FEVER
JAMES F. RINEHART, M.D.;
LOUIS D. GREENBERG, Ph.D.;
MARY OLNEY, M.D.;
FRANK CHOY, A.B.
Arch Intern Med. 1938;61(4):552-561.
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Since the suggestion was originally made that vitamin C deficiency may be an important factor in the etiology of rheumatic fever,1 there has been considerable study of this problem. The concept was based on experimental observations that a pathologic state with certain similarities to rheumatic fever may be produced by subjecting guinea pigs to the simultaneous influence of vitamin C deficiency and streptococcic infection. The reports recorded the occurrence of lesions comparable to those of rheumatic fever in the cardiac valves, cardiac muscle and joints of the experimental animals so treated. The well known epidemiologic peculiarities of rheumatic fever, notably the geographic, seasonal and social incidence, are in accord with such a concept. A conditioning environmental influence is suggested particularly by the dominant occurrence of the disease in the poor.
Stimson, Hedley and Rose2 soon offered confirmation of the experimental work and added a brief report on the
. . . [Full Text PDF of this Article]
Author Affiliations
SAN FRANCISCO
From the Division of Pathology and the Division of Pediatrics, the University of California Medical School.
Footnotes
Read before the American Rheumatism Association, Atlantic City, N. J., June 7. 1937.
This investigation was supported by the Christine Breon Fund for Medical Research and by the California Fruit Growers' Exchange. Hoffmann-LaRoche, Inc., furnished supplies of vitamin C.
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