This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. ANATOMIC CHANGES IN MAN COMPARED WITH THOSE IN DOGS WITH EXPERIMENTAL HEMOGLOBINURIA

ELMER L. DeGOWIN, M.D.; E. D. WARNER, M.D.; WILLIAM L. RANDALL, M.D.

Arch Intern Med. 1938;61(4):609-630.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The transfusion of incompatible blood into man is accompanied with or immediately followed by chills, fever, nausea and vomiting, acute pains in the muscles, dyspnea and a feeling of constriction in the chest. Signs of hemolysis in vivo may occur within a few hours. These include hemoglobinemia, hemoglobinuria and jaundice. If a relatively small amount of blood is hemolyzed, hemoglobinuria and jaundice may not be evident. Drabkin¹ has shown that only about 10 per cent of the hemoglobin that disappears from the blood stream of the dog appears in the urine. The patient may recover with nothing more serious than the loss of the transfused erythrocytes and consequent hemoglobinuria for several days. In some cases, however, the sequelae are more grave. The urinary excretion is immediately diminished, or ceases entirely, and the products of nitrogen metabolism increase rapidly in the blood. Vomiting continues, and generalized edema sometimes appears. Coma . . . [Full Text PDF of this Article]

Author Affiliations
Associate in Internal Medicine; Assistant Professor of Pathology; Assistant in Internal Medicine IOWA CITY

From the Department of Internal Medicine and the Department of Pathology, the State University of Iowa College of Medicine.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?