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A METHOD OF ASSAY OF THYROTROPIC SUBSTANCE; CLINICAL APPLICATION

RULON W. RAWSON, M.D.; PAUL STARR, M.D.

Arch Intern Med. 1938;61(5):726-738.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A convenient, specific and delicate method of assay of the thyrotropic principle of the anterior lobe of the pituitary body is required for physiologic and clinical studies. Various methods have been used. Loeb¹ and his associates, in 1928, described a quantitative method that had been used by them for several years, namely, the determination of the mitotic index. The entire thyroid gland of the test animal, the guinea pig, was cut in serial section and stained with hematoxylin and eosin. The average number of sections obtained for each gland varied between four hundred and fifty and five hundred; mitoses were counted in every tenth section in an exact manner; the number of mitoses thus obtained was multiplied by 10 to obtain the total number of mitoses in the gland. A marked increase in the number of mitoses occurs with thyroid hypertrophy.

Several workers have described the degrees of hyperplastic . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine, Northwestern University Medical School.

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