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PHYSIOLOGIC OBSERVATIONS

J. M. McCAUGHAN, M.D., Ph.D.; B. L. SINNER, M.D.; C. J. SULLIVAN, M.D.

Arch Intern Med. 1938;61(5):739-754.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The earliest basic knowledge of the physiology of the external function of the pancreas came largely as a result of the pioneer studies of two eminent experimental physiologists, Claude Bernard¹ and Ivan Pavlov.² The former, in 1856, showed that pancreatic juice is highly essential to digestion; the latter, in 1902, demonstrated the existence of pancreatic enzymes. In the same year Bayliss and Starling³ investigated the factors concerned in the secretory stimulus of the pancreas and assigned the important role to a humoral mechanism which they named secretin.

Many valuable contributions to the physiology of the pancreas have been made during the past thirty years, and McClure⁴ in a recent paper has enumerated as follows the important physiologic facts which are now firmly established: 1. Stimulation of the external secretion of the pancreas is of humoral origin, but the exact mechanism remains undetermined. 2. The ingestion of . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Surgery and the Department of Medicine, St. Louis University School of Medicine.

Footnotes
Based on material presented in lantern slides by Dr. J. M. McCaughan, at the Eighty-Eighth Annual Session of the American Medical Association, Atlantic City, N. J., June 10, 1937.

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