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MARGARET DANN, M.D., Ph.D.; GEORGE R. COWGILL, Ph.D.

Arch Intern Med. 1938;62(1):137-150.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chronic diarrhea occurs as a symptom in a great variety of diseases (table 1). In the management of the majority of these conditions, one of the problems of prime importance is the assurance of an adequate supply of dietary essentials. Without intending to minimize the importance of mineral constituents or of the other substances known to be necessary in the diet, we present this study concerned with one particular aspect of the problem, namely, the amount of vitamin B₁ which may be required by patients suffering from diarrhea. The literature contains abundant clinical evidence that disorders due to dietary deficiencies, usually multiple but particularly of the vitamins of the B complex, occur as complications of chronic diseases of the alimentary tract. Signs and symptoms of pellagra and beriberi have been observed in carcinoma of the gastrointestinal tract (Rolph,¹ 1916; Eusterman and O'Leary,² 1931), in ulcerative colitis (Barnes, . . . [Full Text PDF of this Article]

Author Affiliations
NEW HAVEN, CONN.

From the Laboratory of Physiological Chemistry, Yale University School of Medicine.

Footnotes
This project was aided by a grant from General Mills, Inc.

Throughout this paper the term milligram equivalent is used to indicate 0.05 U. S. P. unit (Cowgill, G. R.: The Vitamin B Requirement of Man, New Haven, Conn., Yale University Press, 1934.

Fellow of the Henry Strong Denison Foundation for Medical Research, 1934-1935. The data presented in this article are from a thesis submitted to the faculty of the Yale University School of Medicine in partial fulfilment of the requirements for the degree of Doctor of Medicine.

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