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WILLIAM B. WOOD, M.D.; CHARLES A. JANEWAY, M.D.

Arch Intern Med. 1938;62(1):151-159.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a lecture delivered before the Royal College of Surgeons in February 1896, Starling¹ predicted on theoretic grounds that "hydraemic plethora" must accompany congestive heart failure. Thirteen years later he was able to confirm the prediction by direct observation of a dog suffering from chronic myocardial insufficiency.² By bleeding the ailing animal he recovered 500 cc. of blood, as compared with 300 cc. from a normal dog of the same size. In 1902 Smith,³ using the Haldane carbon monoxide inhalation method of determining the volume of the blood, demonstrated a state of plethora in a case of congestive heart failure due to an adherent pericardium. Although Bock⁴ reported finding a normal blood volume in a case of cardiac failure, more recent investigations with carbon monoxide inhalation and various dye methods⁵ have indicated abnormally high blood volumes for patients suffering from uncomplicated heart failure.⁶ In addition, these studies . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Medicine, Johns Hopkins University Medical School.

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