This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A NEW, SLOWLY ABSORBED EPINEPHRINE PREPARATION

EDMUND L. KEENEY, M.D.; J. A. PIERCE, Ph.D.; LESLIE N. GAY, M.D.

Arch Intern Med. 1939;63(1):119-142.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Interest in compounds that produce a rise in blood pressure was aroused by Oliver and Schäfer¹ in 1894, when they found that extracts of the adrenal gland when injected intravenously into animals produced a rise in blood pressure. Intensive study of the gland was begun by Abel,² von Fürth³ and Takamine.⁴ It remained for Aldrich⁵ to demonstrate the true formula for epinephrine, although the value of Abel's contributions is well recognized by the scientific world and it is he who is generally accorded the credit for the first isolation of the principle. This principle he named "epinephrin," while von Fürth and Takamine, respectively, suggested the names "suprarenine" and "adrenalin."

Since the isolation of epinephrine, investigators have attempted to produce more active compounds with more prolonged effectiveness by modifying the structure of the molecule. Although a few changes have resulted in more active preparations, these, in . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Protein Clinic, Department of Medicine, and the Department of Pediatrics, Johns Hopkins Medical School and Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?