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ANCEL KEYS, Ph.D.; HUGH R. BUTT, M.D.

Arch Intern Med. 1939;63(1):165-172.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Quiet standing results in hemoconcentration, generally referred to a loss of fluid by transudation to the tissue spaces of the extremities.¹ The alterations in the blood are similar to those produced by simple venous stasis.² Along with a general rise in the concentration of the blood there is a marked increase in the colloid osmotic pressure of the serum under these conditions.³

Man and Peters⁴ found that the rise in the concentration of plasma protein with standing is paralleled, in general, by rises in the concentrations of cholesterol, fatty acids and lipoid phosphorus in the serum. They concluded that the capillaries are equally impermeable to all these substances. This conclusion is important enough to warrant independent confirmation. In particular it appears that possible osmotic consequences should be studied.

There is still some uncertainty as to whether the capillaries are, under these conditions, completely impermeable to protein. . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Biochemistry of the Mayo Foundation and the Division of Medicine of the Mayo Clinic.

Footnotes
Now associate Professor of Medicine and Education, University of Minnesota.

This work was done in the Division of Biochemistry of the Mayo Foundation, and this paper represents part of the work for which the John Horsley Memorial Prize for 1938 was awarded to Dr. Butt by the University of Virginia.

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