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A VARIABLE SYMPTOM COMPLEX OF UNDETERMINED ETIOLOGY WITH FATAL TERMINATIONINCLUDING CONDITIONS DESCRIBED AS VISCERAL ERYTHEMA GROUP (OSLER), DISSEMINATED LUPUS ERYTHEMATOSUS, ATYPICAL VERRUCOUS ENDOCARDITIS (LIBMAN-SACKS), FEVER OF UNKNOWN ORIGIN (CHRISTIAN) AND DIFFUSE PERIPHERAL VASCULAR DISEASE (BAEHR AND OTHERS)
EDWARD C. REIFENSTEIN, M.D.;
EDWARD C. REIFENSTEIN, Jr., M.D.;
GEORGE H. REIFENSTEIN, M.D.
Arch Intern Med. 1939;63(3):553-574.
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The medical literature contains descriptions of a condition characterized by all or many of the following features: prolonged fever, polyarthritis, polyserositis, endocarditis, erythematous cutaneous lesions, nephritis, anemia and a remittent cachectic course, with a fatal termination months to several years after the onset. This variation in the characteristics and the unknown cause of the condition have resulted in the application of a great variety of names to this syndrome, depending on the symptom complex or pathologic lesion which most impressed each author. The purpose of this communication is to present a similar case with necropsy studies.
REVIEW OF THE LITERATURE
The association of visceral lesions with diseases of the skin has long been recognized. The reports by Osler1 in 1904 of 2 cases of "visceral manifestations of the erythema group of skin diseases" may be early descriptions of the condition under discussion. When case reports2 of "lupus erythematosus
. . . [Full Text PDF of this Article]
Author Affiliations
SYRACUSE, N. Y.
From the Department of Medicine of the Syracuse University College of Medicine and the Medical Service of the Syracuse University Hospital.
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