This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

H. A. LINDBERG, M.D.; M. H. WALD, M.D.; M. HERBERT BARKER, M.D.

Arch Intern Med. 1939;63(5):907-918.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Because of the widespread use of hypertonic solutions for intravenous administration in modern clinical practice we became interested in the question whether renal damage resulted from the employment of such solutions and, if so, what the nature and extent of this damage might be. In recent years the intravenous administration of hypertonic solutions of dextrose has become increasingly popular. Lately 50 per cent sucrose has gained wide vogue in the treatment of cerebral edema, glaucoma and retention of fluid resulting from a variety of causes.¹ This material has been rapidly replacing the older dextrose solution for this type of therapy.

Helmholz² reported on a series of experiments on rabbits given single and multiple injections of 50 per cent solution of sucrose at various intervals and pathologic studies of the kidneys made at intervals of one to seven days after the final injection of the material. Included in his . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine, Northwestern University Medical School, and the Medical Service of the Passavant Memorial Hospital.

Footnotes
Kenneth Smith Fellow in Medicine.

Abbott Laboratories supplied this material. The compound d-sorbitol is an alcohol obtained by the reduction of dextrose, is optically dextrorotary and has the following formula: CH2OH—(CHOH)4—CH2OH.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?