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A REVIEW OF THE LITERATURE

CYRUS C. STURGIS, M.D.; RAPHAEL ISAACS, M.D.; S. MILTON GOLDHAMER, M.D.; FRANK H. BETHELL, M.D.

Arch Intern Med. 1939;64(1):148-212.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ANEMIA OF PREGNANCY

Experimental studies of the effects on the blood of iron deficient diets given to rats throughout gestation and lactation have been discussed earlier in this review,¹⁵⁹ A macrocytic form of anemia in pregnant rats has been produced by Kyer and Bethell¹⁶⁰ by means of diets deficient in protein. Such anemia is accompanied by characteristic changes in the percentage and absolute number of the nucleated cells in the several stages of erythrocytic development represented in the marrow.¹⁶¹ The specific alteration in erythropoiesis is a "shift" to the more immature nucleated red blood cells, analogous to the "megaloblastic block" found in the marrow of patients with pernicious anemia. In rats receiving an inadequate amount of protein during gestation there is also extensive lipoidosis of the liver, arising first in the central zones of the hepatic lobules. An etiologic relation between hepatic damage, induced by deficient diets, . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH.

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