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CHARLES LEROY STEINBERG, M.D.; LOUISE CATHERINE SUTER

Arch Intern Med. 1939;64(3):483-492.

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The presence of a ferment, phosphatase, in the bones of young rats was demonstrated by Robison¹ in 1932. This ferment hydrolyzes the phosphoric esters of hexosephosphate, glycerophosphate and nucleoprotein. One of the resulting products of such hydrolysis is inorganic phosphorus. Therefore, this ferment plays an important role in the deposition of calcium in bone, in carbohydrate metabolism, in renal metabolism and indirectly in the maintenance of the proper hydrogen ion concentration of blood. Its ubiquitous nature in body tissues has been shown by Bodansky² and Kay.₃ So complex are the physiologic functions of phosphatase that the complexity can be matched only by the chemical complexity of the liver itself. All investigators have found an increase of serum phosphatase in such diverse diseases as osteitis deformans,⁴ hyperparathyroidism,⁵ rickets⁵ and obstructive jaundice.⁶ The exact significance of this increase is unknown. Regarding other conditions, notably chronicatrophie arthritis and the healing of bone . . . [Full Text PDF of this Article]

Author Affiliations
Physician-in-Charge, Arthritic Clinic, Rochester General Hospital; Technician to the Private Laboratories of Dr. Steinberg ROCHESTER, N. Y.

From the Department of Medicine and the Arthritic Clinic of the Rochester General Hospital and the private practice of the authors.

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