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By Ralph R. Mellon, M.D.; Paul Gross, M.D., and Frank B. Cooper, of the Institute of Pathology, Western Pennsylvania Hospital, Pittsburgh. Price, $4. Pp. 398, with tables and graphs. Springfield, Ill.: Charles C. Thomas, Publisher, 1938.

Arch Intern Med. 1939;64(3):659-660.

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Advances in the knowledge of the types, actions, uses and chemotherapeutic implications of the sulfanilamide compounds have been so rapid that the need for a comprehensive summary of the facts has become very real. This need has been well met by the authors of this book in their first section, which comprises a review, with a bibliography, of all the literature on the sulfonamide group of drugs. This review should be immensely useful to both clinicians and laboratory workers in various phases of chemotherapeutic research. The clinician will be particularly interested in the chapters devoted to the indications, routes of administration, schemes of dosage, toxic manifestations and results of sulfanilamide therapy in various infections. The second section of the book deals with the authors' experiments on the bacteriostatic action of sulfanilamide and emphasizes the great discrepancies between the in vitro and the in vivo effects of the drug. Some possible . . . [Full Text PDF of this Article]

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