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ALFRED CHANUTIN, Ph.D.; STEPHAN LUDEWIG, Ph.D.

Arch Intern Med. 1939;64(4):756-766.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Numerous workers 1 have reported that the administration of yeast extracts to white rats is effective in preventing renal hypertrophy caused by excessive ingestion of protein. There are no data showing the possible relation between the size and the function of the kidneys under such conditions. This investigation was undertaken to study the effect of feeding diets containing varying concentrations of dried yeast on renal hypertrophy, renal function and blood pressure in intact and in partially nephrectomized rats.

EXPERIMENTAL METHODS

The details of the procedures for the care of the animals and for determining the blood pressure and renal function have been presented in previous papers.² Eighty to 90 per cent of the total kidney tissue was removed by a two stage operation from the partially nephrectomized rats.

Five experimental diets were used and were designated as Y 20, Y 30, Y 40, Y 60 and Y 80 according . . . [Full Text PDF of this Article]

Author Affiliations
UNIVERSITY, VA.

From the Laboratory of Physiological Chemistry, the University of Virginia.

Footnotes
The dried yeast was contributed by Standard Brands, Inc.

This work was aided by a grant from the Penrose Fund of the American Philosophical Society.

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