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MORTON F. MARK, M.D.

Arch Intern Med. 1939;64(5):897-906.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Hagedorn, Norman Jensen, Krarup and Wodstrup,¹ who were the first to use protamine insulin, gave in most of their cases a dose of protamine insulin in the evening and one of regular insulin in the morning. The addition of zinc to protamine insulin by Scott and Fisher² prolonged the action of the new preparation considerably, so that a single injection a day was sufficient to control the diabetes in a large percentage of cases.. Sprague and his associates³ adopted the procedure of giving the single dose of protamine zinc insulin early in the morning, and their method was soon followed by most investigators (Campbell and his associates,⁴ Joslin,⁵ Rabinowitch⁶ and others). In previous studies (Mosenthal⁷ and Mark, Sackey and Mosenthal⁸) in which a single dose of protamine zinc insulin was administered at 6 or 7 a. m., it was found that there was a rise of the level of sugar . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Metabolism, Sea View Hospital and New York Post-Graduate Hospital, Dr. Herman O. Mosenthal, Director.

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