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I. CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: AN INVESTIGATION OF THE MECHANISM OF HEMOLYSIS, WITH OBSERVATIONS ON FIVE CASES

THOMAS HALE HAM, M.D.

Arch Intern Med. 1939;64(6):1271-1305.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The disease syndrome of chronic hemolytic anemia associated with paroxysmal nocturnal hemoglobinuria was described as a separate entity in 1928 and 1931 by Marchiafava¹ and in 1931 by Micheli.² The clinical manifestations have been reviewed recently with the report of cases by Witts³ and by Hamburger and Bernstein.⁴ The pathologic observations in 2 cases, with a review of the literature, were reported in 1938 by Scott, Robb-Smith and Scowen.⁵ Van den Bergh⁶ in 1911 made important observations on the in vitro manifestations of this disease without distinguishing it from acholuric hemolytic jaundice. A preliminary report on the mechanism of hemolysis was published in 1937 by Ham;⁷ these observations were confirmed in 1938 by Dacie, Israëls and Wilkinson.⁸ Jordan⁹ in 1938 published independent observations on the hemolytic mechanism.

The present communication deals with the relation of the acid-base equilibrium of blood to hemolysis in vivo and in vitro and with observations . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
This investigation was aided in part by a grant from the Transfusion Betterment Association, Inc., New York City, and by a grant from the Penrose Fund of the American Philosophical Society.

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