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A FORMULA FOR COMPENSATION OF THIS FACTOR OF ERROR

JOHN B. LUDDEN, M.D.; IRVING WRIGHT, M.D.

Arch Intern Med. 1940;65(1):151-162.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1933, Harris, Ray and Ward¹ demonstrated the excretion of vitamin C in the urine and established a relationship between the excretion and the intake of this vitamin. Since that time, a number of chemical methods for the determination of the state of vitamin C nutrition in man have been presented. The determination of the twenty-four hour "resting level" of urinary excretion presented many technical disadvantages and was impractical in the study of ambulatory patients. The content of ascorbic acid in the fasting blood was observed to vary considerably with the recent dietary intake of vitamin C and gave only a rough index of the actual state of saturation.² The test dose method, in which a given dose of ascorbic acid is administered and the output in the urine is used as an index of saturation, was found to have many advantages. Oral test doses of 300 to . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Medicine of the New York Post-Graduate Medical School and Hospital.

Footnotes
This study was aided by a grant from Merck & Co., Inc., Rahway, N. J., who also furnished the ascorbic acid used.

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