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A FURTHER STUDY OF THE ROLE OF ACID GASTRIC JUICE IN THE PATHOGENESIS OF PEPTIC ULCER

WALTER LINCOLN PALMER, M.D.; PAUL B. NUTTER, M.D.

Arch Intern Med. 1940;65(3):499-509.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The concept that acid gastric juice plays an essential role in the genesis of peptic ulcer is supported by a great deal of clinical, pathologic and experimental evidence. A number of points, however, are not yet clear. Apparently incompatible with this thesis is the alleged occurrence of chronic ulcer with achlorhydria. In this paper we wish to consider the question as to whether or not peptic ulcer occurs in the complete absence of acid gastric juice.

In 1926 one of us (W. L. P.) reviewed the literature on this subject, studied a group of cases and concluded that there was no conclusive evidence that chronic ulcer occurs in the complete absence of acid gastric juice.¹ The evidence usually offered to prove that ulcer may occur in the presence of achlorhydria was found inadequate either in demonstrating achlorhydria or in establishing the presence of chronic benign ulcer, or, indeed, in . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine, the University of Chicago.

Footnotes
A brief résumé of this paper was presented before the Association of American Physicians at Atlantic City, N. J., May 2, 1939.

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