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A CLINICOPATHOLOGIC STUDY

EDWARD F. ROSENBERG, M.D.

Arch Intern Med. 1940;65(3):545-586.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

As a result of the original concepts of Volhard and Fahr,¹ a malignant (bösartig) form of hypertension was separated from the general group in 1914. In 1924, however, Wagener and Keith² described a syndrome of malignant hypertension and showed that this condition deserves the distinction of an entity, differing from chronic glomerulitis and benign hypertension on the basis of age incidence, a characteristic retinal picture, absence of anemia and frequent persistence of adequate renal function. This clinical concept of Wagener and Keith was further developed in investigations at the Mayo Clinic, the results of which were published in 1927,³ 1928,⁴ 1929,⁵ and 1931,⁶ and various pathologic studies of this disease have been reported from this institution by Cain,⁷ Morlock⁸ and Odel.⁹ None of these works included any comprehensive data regarding the brain. The purpose of the present study has been to survey the brain in cases of malignant hypertension, to . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, the Mayo Foundation ROCHESTER, MINN.

From the Division of Medicine, Section of Pathologic Anatomy and Section of Ophthalmology, the Mayo Clinic.

Footnotes
Objection has been raised to the use of the term malignant hypertension. In this paper, the term has been used interchangeably with diffuse arteriolar disease with hypertension, group 4.

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