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FURTHER STUDIES ON SENSITIVITY TO ARSPHENAMINE AND TOLERANCE TO MAPHARSEN

ERNEST H. FALCONER, M.D.; NORMAN N. EPSTEIN, M.D.

Arch Intern Med. 1940;65(6):1158-1177.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1936 studies on 3 patients with purpura haemorrhagica following neoarsphenamine therapy were reported.¹ We ascertained by experiments that 2 of these patients were very sensitive to neoarsphenamine but apparently not sensitive to mapharsen, as the intravenous injection of this arsphenamine derivative failed to produce any significant effects on the platelets and capillaries or any untoward constitutional reaction. The third patient of the series disappeared from observation after leaving the hospital; hence no experimental studies were made.

Since publication of the report mentioned, we have had an opportunity to study 6 additional patients who showed hemorrhagic phenomena following the therapeutic use of arsphenamine derivatives. It appeared to us important to record our experimental studies on these patients, particularly those on 5 patients of the series who showed typical purpura haemorrhagica following the use of neoarsphenamine or of bismarsen but who had no apparent reaction following the intravenous injection of . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Divisions of Medicine and Dermatology of the University of California Medical School.

Footnotes
Supported by a grant from the Christine Breon Fund.

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