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WITH AN EVALUATION OF THE CLINICAL SIGNIFICANCE OF THIS DETERMINATION

ALF S. ALVING, M.D.; BENJAMIN F. MILLER, Ch.E., M.D.

Arch Intern Med. 1940;66(2):306-318.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The kidney, by virtue of its peculiar structure, lends itself particularly well to quantitative measurements. Until recently most studies concerning the quantitative aspects of renal function have dealt with the excretion of urea and exogenous creatinine. The extensive studies of Ambard,¹ Addis,² and Möller, McIntosh and Van Slyke³ have developed the laws governing the excretion of urea by the normal and the diseased human kidney. These studies have led to practical tests of renal function. Of these, the Ambard coefficient is now of historical interest only. The Addis urea ratio, though somewhat too complicated for routine use, is a good quantitative test of renal function. The urea clearance test of Van Slyke and his associates has been adopted universally as a simple and precise estimate of the functional state of the kidneys. Recent studies⁴ have shown that the excretion of urea depends on a balance between the glomerular filtration rate . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Medicine, University of Chicago.

Footnotes
This work was aided by a grant from the Douglas Smith Foundation for Medical Research, University of Chicago. A preliminary report of this work was presented before the Central Society for Clinical Research, Chicago, Nov. 3, 1939.

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