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SENSITIVITY IN PATIENTS AS INFLUENCED BY VITAMIN C THERAPY

ERNEST H. FALCONER, M.D.; NORMAN N. EPSTEIN, M.D.; EDITH S. MILLS, M.A.

Arch Intern Med. 1940;66(2):319-338.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since 1933 we have had an opportunity to study 7 patients showing reactions accompanied by thrombopenic purpura following arsphenamine therapy. These patients have submitted to further injections of arsphenamine preparations; thereby we have been allowed to reproduce experimentally their attacks of purpura. An opportunity has thus been afforded for study of the effects of oral and parenteral administration of vitamin C on this type of sensitivity.

Our interest in the effect of vitamin C on purpura due to administration of neoarsphenamine was stimulated by reports in the literature that tended to show a relationship between vitamin C deficiency and arsphenamine sensitivity and also by reports of the clinical use of vitamin C as an agent to ameliorate the toxic effects of the arsphenamines. We have been interested also in several reports concerning the therapeutic value of ascorbic acid in the treatment of patients having idiopathic thrombopenic purpura. In 1935 Sulzberger . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Medicine and the Department of Dermatology of the University of California Medical School.

Footnotes
This study was aided by a grant from the Christine Breon Fund.

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