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HOWARD M. ODEL, M.D.

Arch Intern Med. 1940;66(3):579-602.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

That diffuse arteriolar changes occur in the presence of essential hypertension seems well established. However, controversy exists concerning the exact nature, distribution, frequency of occurrence and severity of these changes.

Numerous investigators (Keith, Wagener and Kernohan;¹ Cain;² Moritz and Oldt;³ Fishberg;⁴ Pilcher and Schwab;⁵ Morlock,⁶ and others) have studied the changes occurring in the arterioles of selected organs in cases of hypertension. It has been reported by some investigators (Fishberg; Pilcher and Schwab) that when hypertension is present the changes noted in the arterioles of other organs almost never are observed in the arterioles of the myocardium.

LITERATURE

The first suggestion as to the occurrence of vascular change in association with hypertension was embodied in the observation of Bright⁷ in 1836 that certain patients who had chronic Bright's disease also had noticeable thickening of the blood vessels.

Johnson,⁸ in 1850, observed thickening of the arterior walls of the kidney in . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Medicine, the Mayo Clinic.

Footnotes
Some objection has been raised to the use of the term "malignant hypertension." In the following report, the terms "diffuse arteriolar disease with hypertension group 4" and "malignant hypertension" have been used interchangeably.

Abridgment of a thesis submitted to the Faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of Master of Science in Medicine. (Work done in the Section on Pathologic Anatomy.)

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