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A COMPARATIVE STUDY

MANDRED W. COMFORT, M.D.; ARNOLD E. OSTERBERG, Ph.D.

Arch Intern Med. 1940;66(3):688-706.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Secretory activity of the pancreas may be stimulated by either a humoral (secretin) or a neural (vagal) mechanism. The amount and type of secretion produced by the two mechanisms has been shown to differ widely in animals. Stimulation with secretin produces a large volume of pancreatic juice rich in bicarbonate and poor in enzymes, whereas vagal stimulation produces a scant flow of juice poor in bicarbonate and rich in enzymes. Mellanby¹ hypothesized that the content of enzymes in the pancreatic juice is determined by action of the vagus nerves, whereas the concentration of the bicarbonate solution in which these enzymes are contained is determined by the action of secretin. In a clinical study of pancreatic function, the response of the pancreas to both types of stimulants should be determined in order to obtain a complete picture.

In man, the effect of intravenous injection of purified secretin was first studied, . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

From the Division of Medicine (Dr. Comfort) and the Division of Biochemistry (Dr. Osterberg), the Mayo Clinic.

Footnotes
Read at a meeting of the Central Society for Clinical Research, Chicago, Nov. 4, 1939.

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