
The General Tissue and Humoral Response to an Avirulent Tubercle Bacillus Including Growth Characteristics of the Organism.
By Sol Roy Rosenthal. Paper. Price, $2.50. Pp. 184, with 80 illustrations. Urbana, Ill.: University of Illinois Press, 1938.
Arch Intern Med. 1940;66(3):782-783.
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This book reports work done on certain phases of growth of B C G and on the response of the tissues and blood of the guinea pig to B C G given by different routes.
The organism was found to have a cycle of growth resembling that previously described for the virulent tubercle bacillus, with passage through a granular phase. There was no reversion to virulent form in this work.
Tissue response was judged by alterations found in the reticuloendothelial system of body organs with sacrifice of the animals at various periods. This response varied from slight swelling of the cells to increase in number and further to grouping of the cells, often in characteristic tubercles. This reaction was limited variously in time and extent and then regressed.
The report is in monographic style and has a good bibliography. The descriptions of tissues are clear and convincing. Repetition of the
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