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RAY D. WILLIAMS, M.D.; HAROLD L. MASON, Ph.D.; RUSSELL M. WILDER, M.D., Ph.D.; BENJAMIN F. SMITH, M.D.

Arch Intern Med. 1940;66(4):785-799.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Reports of controlled observations on induced thiamine (vitamin B₁) deficiency in human beings have been few,¹ and in only two of these reports^1c,d has the restriction of vitamins been limited to thiamine. One of these studies^1d was reported by three of us (Williams, Mason and Smith) in December 1939. In that study, 4 young women for twenty-one weeks received a diet which was more deficient in vitamin B₁ than commonly is reported in association with the syndrome of beriberi. This diet was made adequate in vitamin A, ascorbic acid, proteins and minerals and in addition was supplemented with crystalline preparations of riboflavin and nicotinic acid. The delayed development of symptoms and failure of the subjects to show the classic signs of beriberi prompted repetition of the study with other subjects. Also it seemed desirable to provide more adequately for the factors of the vitamin B complex other than thiamine. For . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, the Mayo Foundation; ROCHESTER, MINN.

From the Rochester State Hospital and the Mayo Foundation.; From the Division of Biochemistry (Dr. Mason), the Mayo Clinic, and from the Departments of Medicine (Dr. Wilder) and of Neurology and Psychiatry (Dr. Smith), the Mayo Foundation.

Footnotes
Presented in abstract to the American Institute of Nutrition, New Orleans, March 13, 1940.

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