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WITH SPECIAL REFERENCE TO DIFFUSE ARTERIOLAR DISEASE WITH HYPERTENSION

ARNOLDUS GOUDSMIT, Jr., M.D.; NORMAN M. KEITH, M.D

Arch Intern Med. 1940;66(4):816-832.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The accumulation of inorganic sulfate in human serum above normal limits in advanced stages of renal disease was first observed by Denis¹ in 1921. Subsequent work by various groups of investigators (Denis and Hobson;² Loeb and Benedict;³ Cope;⁴ Hayman and Johnston⁵) substantiated these observations. Wakefield, Power and Keith⁶ pointed out that sulfate, the concentration of which normally is not in excess of 5.5 mg.⁷ per hundred cubic centimeters of serum, in an appreciable number of cases actually is the first substance to accumulate in the blood of patients with early renal insufficiency. Macy,⁸ amplifying the scope of the problem, investigated the clearance of inorganic sulfate. He found a certain number of patients in whom renal damage could be expected to exist whose clearance of inorganic sulfate was less than 20 cc. per minute (which he considered the lower limit of normal), whereas with none of the other tests of renal . . . [Full Text PDF of this Article]

Author Affiliations
Fellow in Medicine, the Mayo Foundation; ROCHESTER, MINN.

From the Division of Medicine, the Mayo Clinic.

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