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ACTION OF ADRENAL CORTICAL EXTRACTS

JAMES A. GREENE, M.D.; GEORGE W. JOHNSTON, M.S.

Arch Intern Med. 1940;66(5):1052-1059.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The action of adrenal cortical extract and the cause of crisis in Addison's disease are still not understood. The disturbance in sodium chloride metabolism was pointed out by Loeb¹ when he observed the beneficial effect of the administration of these electrolytes. Later, Harrop and his co-workers² showed that alteration of the sodium metabolism was the more important of the two. The importance of disturbed potassium metabolism in patients has been emphasized by Wilder and his associates³ and by Zwemer and Truszkowski.⁴ A study of the sodium, potassium and chloride excretion of 2 patients with Addison's disease showed several points of interest and prompted this report.

Both patients had undoubted moderately severe Addison's disease, and they had not received any previous treatment. The first was a youth 18 years of age and the second a woman 24 years of age. The first patient was studied for one hundred and fifty-nine consecutive . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Department of Internal Medicine, State University of Iowa College of Medicine.