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A CLINICAL AND EXPERIMENTAL STUDY WITH A REPORT OF RESULTS OF TREATMENT

ARTHUR M. GREENE, M.D.

Arch Intern Med. 1941;67(1):114-128.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical signs and symptoms of myxedema are well known. However, prior to the last decade too little attention was directed to the biochemical processes of the disease. Hypothyroidism presumably results from a relative or an absolute deficiency of thyroid secretion. Since iodine comprises about 65 per cent of thyroxin, it would appear that further investigation of the metabolism of iodine as evidenced by the iodine levels of the blood and urine is indicated.

A characteristic alteration of the plasma cholesterol is found in patients with thyroid deficiency. This aspect has been investigated by several workers both before and after treatment with desiccated thyroid. The results of these investigations have shown that the level of the cholesterol in the blood is of value in the differential diagnosis of borderline cases of hypothyroidism.

This study had as its purpose the following determinations:

1. The level of the iodine in the blood
   

Author Affiliations
OMAHA

Footnotes
From the Lahey Clinic, Boston. A thesis submitted to the Faculty of the Graduate School of Medicine of the University of Pennsylvania in partial fulfilment of the requirements for the degree of Master of Medical Science (M.Sc., Med.) for graduate work in internal medicine.

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