This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CLINICAL APPLICATION AND SIGNIFICANCE OF SUCH CURVES IN THE TREATMENT OF PATIENTS WITH SEVERE DIABETES

HELEN EASTMAN MARTIN, M.D.; PAUL O. GREELEY, M.D.

Arch Intern Med. 1941;67(1):194-206.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Among the roles played by insulin in carbohydrate metabolism, two have been stressed in previous publications from this laboratory.¹ These roles may be summarized briefly as follows: (1) the control of new sugar formation in the fasting state, taken care of by the "basal insulin," and (2) the dextrose-disposing mechanism of insulin, operating by oxidation or storage.

It has been shown by many observers that the depancreatized dog in the fasting state has a high blood sugar level. The maintenance of a constant normal blood sugar level in the fasting diabetic dog requires the intravenous injection of insulin at the rate of 0.0051 to 0.035 unit per kilogram per hour, as shown by Greeley^la and Houssay.² Evidence that certain patients with severe diabetes may also have a rising blood sugar level in the fasting state has been reported by Martin, Drury and Strouse.^1c They showed that . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

From the Departments of Physiology and Medicine of the School of Medicine of the University of Southern California and the Department of Medicine of the Los Angeles County Hospital (services of Dr. Solomon Strouse and Dr. Howard West).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?