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CONSTITUTIONAL HEPATIC DYSFUNCTION WITH INDIRECT VAN DEN BERGH REACTION

WILLIAM DAMESHEK, M.D.; KARL SINGER, M.D.

Arch Intern Med. 1941;67(2):259-285.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Jaundice of the familial type is almost invariably considered to be hemolytic. Congenital or familial hemolytic (acholuric) icterus is a well defined disease entity. That there are instances of familial icterus in which all the evidences of excessive blood destruction are lacking has only occasionally been recognized. We have recently observed two families in which, although bilirubinemia of the "indirect" type was present, there were the signs neither of hepatic disease nor of splenomegaly, increased fragility of the red cells or reticulocytosis. The urine was free of bilirubin and did not contain increased quantities of urobilinogen, and the results of hematologic examinations were uniformly normal. Final proof of the nonhemolytic character of the icterus in these families was obtained from study of the urobilinogen content of the feces, which was either normal or slightly decreased.

From 1900 to 1907, Gilbert and his associates¹ described a series of cases of . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Joseph H. Pratt Diagnostic Hospital and the Blood Clinic of the Boston Dispensary.

Footnotes
Aided by grants from the Charlton Fund, Tufts College Medical School; the Proctor Fund, Harvard Medical School, and the Milton Fund of Harvard University.

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