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POSSIBLE IMPLICATIONS OF CHANGES IN THE CREATINE, PHOSPHORUS AND POTASSIUM CONTENT, WITH SPECIAL REFERENCE TO HEART DISEASE

GEORGE H. MANGUN, Ph.D.; HERBERT S. REICHLE, M.D.; VICTOR C. MYERS, Ph.D., D.Sc.

Arch Intern Med. 1941;67(2):320-332.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A number of studies have shown that the creatine concentration of cardiac and voluntary muscle is decreased in certain pathologic conditions. This work has been summarized in an earlier paper from this laboratory.¹ The fundamental cause of the decrease in concentration of creatine in heart failure and other pathologic conditions has not been elucidated. However, certain facts are known that have an important bearing on this subject. Creatine is present in muscle largely in the form of phosphocreatine.² That the exact amount present in this form cannot be determined by analysis is due to its rapid breakdown during manipulation of the sample. The best analyses suggest that about 75 to 80 per cent of the creatine present in voluntary muscle is in the form of phosphocreatine while in cardiac muscle the relative amount present in this form is much lower. Creatine can be readily washed out of cardiac . . . [Full Text PDF of this Article]

Author Affiliations
CHARLESTON, S. C.; CLEVELAND

From the Departments of Biochemistry and Pathology (City Hospital Division), School of Medicine, Western Reserve University.

Footnotes
Aided by a grant from the Josiah Macy Jr. Foundation.

Presented at the thirty-second annual meeting of the American Society of Biological Chemists, Baltimore, April 2, 1938, J. Biol. Chem. 123:lxxix, 1038.

The chemical data in this paper are taken from a dissertation submitted by George H. Mangun to the Graduate School of Western Reserve University, June 1938, in partial fulfilment of the requirements for the degree of Doctor of Philosophy.

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