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HERBERT POLLACK, M.D.; MAX ELLENBERG, M.D.; HENRY DOLGER, M.D.

Arch Intern Med. 1941;67(4):793-804.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The widespread clinical application of vitamin B₁ therapy has been stimulated by the availability of the crystalline substance. Estimates as to dosage and duration of therapy have had to be approximated on the basis of gross clinical changes. The use of this vitamin as a therapeutic test in various confusing syndromes has been expensive to both patient and physician. Furthermore, the negative response to vitamin B₁ in many of these syndromes may discourage its use where it is really indicated.

If a test were available by means of which one could estimate the state of nutrition in a person with respect to vitamin B₁ rapidly and inexpensively, then the clinical application could be placed on a more rational basis.

The methods available up to recently have been long and cumbersome. Schultz, Atkins and Frey developed a method which is comparatively simple and lends itself to clinical investigations. . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Medical Services, Metabolism Clinic and the Division of Laboratories of the Mount Sinai Hospital.

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