This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

SAMUEL BERG, M.D.

Arch Intern Med. 1941;67(5):1050-1060.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Urinary secretion is a mechanical process during which water and solutes are filtered from the blood through the glomerular membranes, while the plasma proteins are retained. Proteins in the urine in abnormal amounts are plasma proteins which have passed through permeable glomeruli; only insignificant amounts originate in the tubules. The mechanical process of glomerular filtration is further evidenced by the fact that protein molecules below a molecular weight of approximately 70,000 (that of hemoglobin) readily escape through the glomeruli, whereas larger protein molecules are usually retained; in other words, the larger the molecular size of the urinary protein, the greater is the glomerular lesion. The albumins, being the smallest of plasma proteins, should appear earliest and in greatest amounts in the urine under abnormal renal conditions. The globulins, which are much larger, should appear only when more severe lesions are present and in lesser amounts than the albumins. Fibrinogen, the . . . [Full Text PDF of this Article]

Author Affiliations
NEWARK, N. J.

From the Metabolic Service of Sea View Hospital, Staten Island, N. Dr. Herman O. Mosenthal, Director.

Footnotes
Formerly assistant attending physician, Sea View Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?